Metabolites at the Host–Gut Microbiota Interface
The ensemble of small-molecule metabolites produced by the gut microbiome, collectively termed the metabolome, plays critical roles in regulating host immune responses. The identities of many bioactive metabolites and their effects on the host, however, have not been fully characterized. We are currently characterizing these metabolites, including which host receptors they engage and their physiological relevance in host defense in various inflammatory and infectious diseases.
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