The Chang Lab is a young, interdisciplinary lab at Cornell University working at the interface of chemical biology, immunology, microbial pathogenesis, and the gut microbiome. We are currently recruiting graduate students and postdoctoral scholars!

Our Research

We are colonized by trillions of microorganisms, including bacteria, viruses, parasites, and fungi, which inhabit the external and internal surfaces of our bodies. It is becoming increasingly evident that these microbes play an important role in regulating many aspects of host physiology, including host defense and immunity. As a result, perturbations to the populations of commensal bacteria have been linked to many inflammatory diseases, including autoimmunity and chronic inflammatory conditions, and susceptibility to infections by microbial pathogens.

Our research focuses primarily on three areas:

(1) We develop activity-based probes to understand the metabolic activity catalyzed by the gut microbiome during different disease state.

(2) We also characterize the small-molecule metabolites produced by the gut microbiota that regulate inflammation during inflammatory diseases and host defense during infection with enteric pathogens.

(3) Building on these discoveries, we develop chemical tools to modulate the immune response using photo-immune modulators to understand the roles of specific immune cell types in vivo.

We employ biological and chemical approaches including the tools of microbiology, chemical biology, chemistry, biochemistry, and molecular and cellular immunology to elucidate key communication pathways between the gut microbiota and the host immune system. Our ultimate goal is to understand how immune homeostasis and host defense are regulated in the intestines, as such discoveries would have broad implications for the development of therapeutics and prophylactics for many inflammatory diseases.

For more information, please see the Research page.

Photo credit: Dennis Kunkel Microscopy


Sept 2020

Kudos to Bibudha, whose paper was accepted by JACS! A HUGE congrats!

Sept 2020

The lab welcomes Russell Barkley, a BBS rotation student! We're thrilled to have you join us!

Aug 2020

The lab welcomes Katrina Callan, a Microbiology rotation student, to the lab! We're excited to host you!!

Jul 2020

The lab welcomes Amanda Conwell, a research technician, to the group! Welcome — we're excited to have you join us!

Jun 2020

Congratulations to Samantha and JJ for their paper being accepted to PNAS! Bravo!!

Mar 2020

Congrats to Pam for being named a Scialog Fellow! Way to go!!

Oct 2019

The lab welcomes Lin Han, a CCB first-year graduate student, to the lab! We are happy to have you as part of the group, Lin!

Sept 2019

Congratulations to Pam for receiving an NIH R35 Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators!

Jul 2019

Check out Bibudha's preprint about our synthetic immunology approach to differentiate Th17 cells on demand on bioRxiv!

May 2019

The lab bids farewell to Gael. Best of luck on your next journey!!

May 2019

Check out Gael's review about metabolites and the gut microbiome, which is featured on the cover, in Trends in Pharmacological Sciences!

Apr 2019

The Chang Lab participates in Expanding Your Horizons (EYH) Outreach Program at Cornell, continuing to inspire young women to pursue careers in STEM fields (check out our new photos in the gallery!).

Apr 2019

Congratulations to Bibudha for his paper being accepted by ACS Central Science! Job well done!!

Mar 2019

Kudos to Jingjing for receiving the prestigious CIHMID postdoctoral fellowship!! Congrats, JJ!

Jan 2019

Welcome postdoctoral associate, Jingjing Fu, to the lab!!

Dec 2018

Congratulations to Pam for winning the Schwartz Travel Award! See the article in the Cornell Chronicle.

Jul 2018

Research in the Chang Lab was highlighted in the Cornell Chronicle at the recent joint Immunology symposium between the Weill Cornell and Ithaca campuses!

June 2018

The Lab welcomes VLP summer student, Jiaming Huang, to the group! Hello, Jiaming!!

Mar 2018

Congratulations to Gael for receiving an Honorable Mention for the Ford Foundation Predoctoral Fellowship!

Dec 2017

Great job, Samantha, for passing her A exam! Congrats!!

Sept 2017

The Chang Lab welcomes undergraduate Hyoann Choi to the group! Welcome, Hyoann!!

Aug 2017

Our lab's research is the focus of Cornell Research! Go, Team!!

Aug 2017

Congrats to Bibudha for passing his A exam! Way to go, Champ!!

May 2017

Congratulations to Pam for receiving a Beckman Young Investigator Award and thank you to the Arnold and Mabel Beckman Foundation for their support! Check out the recent news article in the Cornell Chronicle.

Mar 2017

Congrats to Samantha for receiving an NSF GRFP Honorable Mention!

Oct 2016

Kudos to Bibudha for his paper being accepted to Chemical Science!! Job well done! Check out the press coverage in the Cornell Chronicle and the Cornell Daily Sun!

May 2016

Congrats to Pam for receiving an Affinito-Stewart Grant and thank you to the PCCW for their support!

May 2016

Kudos to Samantha for being awarded the CALS Outstanding TA Award!

May 2016

Welcome new graduate students, Gael and Samantha!

Mar 2016

Congratulations to Samantha for an Honorable Mention in the NSF GRFP competition this year!

Nov 2015

Welcome CCB graduate student Bibudha Parasar to the lab!