The Chang Lab is a young, interdisciplinary lab at Cornell University working at the interface of chemical biology, immunology, microbial pathogenesis, and the gut microbiome. We are currently recruiting graduate students and postdoctoral scholars!
We are colonized by trillions of microorganisms, including bacteria, viruses, parasites, and fungi, which inhabit the external and internal surfaces of our bodies. It is becoming increasingly evident that these microbes play an important role in regulating many aspects of host physiology, including host defense and immunity. As a result, perturbations to the populations of commensal bacteria have been linked to many inflammatory diseases, including autoimmunity and chronic inflammatory conditions, and susceptibility to infections by microbial pathogens.
Our research focuses primarily on three areas:
(1) We develop activity-based probes to understand the metabolic activity catalyzed by the gut microbiome during different disease states.
(2) We also characterize the small-molecule metabolites produced by the gut microbiota that regulate inflammation during inflammatory diseases and host defense during infection with enteric pathogens.
(3) Building on these discoveries, we develop chemical tools to modulate the immune response using photo-immune modulators to understand the roles of specific immune cell types in vivo.
We employ biological and chemical approaches including the tools of microbiology, chemical biology, chemistry, biochemistry, and molecular and cellular immunology to elucidate key communication pathways between the gut microbiota and the host immune system. Our ultimate goal is to understand how immune homeostasis and host defense are regulated in the intestines, as such discoveries would have broad implications for the development of therapeutics and prophylactics for many inflammatory diseases.
For more information, please see the Research page.
Photo credit: Dennis Kunkel Microscopy
The lab welcomes Anne Buglione and Laura Frazier, BBS rotation students, to the lab!! We're looking forward to having you in the group!
Check out Bibudha's First Reaction preview article in ACS Cent Sci!
Kudos to Bibudha, whose paper was accepted by JACS! A HUGE congrats!
The lab welcomes Russell Barkley, a BBS rotation student! We're thrilled to have you join us!
The lab welcomes Katrina Callan, a Microbiology rotation student, to the lab! We're excited to host you!!
The lab welcomes Amanda Conwell, a research technician, to the group! Welcome — we're excited to have you join us!
Congratulations to Samantha and JJ for their paper being accepted to PNAS! Bravo!!
Congrats to Pam for being named a Scialog Fellow! Way to go!!
The lab welcomes Lin Han, a CCB first-year graduate student, to the lab! We are happy to have you as part of the group, Lin!
Congratulations to Pam for receiving an NIH R35 Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators!
Check out Bibudha's preprint about our synthetic immunology approach to differentiate Th17 cells on demand on bioRxiv!
The lab bids farewell to Gael. Best of luck on your next journey!!
Check out Gael's review about metabolites and the gut microbiome, which is featured on the cover, in Trends in Pharmacological Sciences!
The Chang Lab participates in Expanding Your Horizons (EYH) Outreach Program at Cornell, continuing to inspire young women to pursue careers in STEM fields (check out our new photos in the gallery!).
Congratulations to Bibudha for his paper being accepted by ACS Central Science! Job well done!!
Kudos to Jingjing for receiving the prestigious CIHMID postdoctoral fellowship!! Congrats, JJ!
Welcome postdoctoral associate, Jingjing Fu, to the lab!!
Congratulations to Pam for winning the Schwartz Travel Award! See the article in the Cornell Chronicle.
Research in the Chang Lab was highlighted in the Cornell Chronicle at the recent joint Immunology symposium between the Weill Cornell and Ithaca campuses!
The Lab welcomes VLP summer student, Jiaming Huang, to the group! Hello, Jiaming!!
Congratulations to Gael for receiving an Honorable Mention for the Ford Foundation Predoctoral Fellowship!
Great job, Samantha, for passing her A exam! Congrats!!
The Chang Lab welcomes undergraduate Hyoann Choi to the group! Welcome, Hyoann!!
Our lab's research is the focus of Cornell Research! Go, Team!!
Congrats to Bibudha for passing his A exam! Way to go, Champ!!
Congratulations to Pam for receiving a Beckman Young Investigator Award and thank you to the Arnold and Mabel Beckman Foundation for their support! Check out the recent news article in the Cornell Chronicle.
Congrats to Samantha for receiving an NSF GRFP Honorable Mention!
Congrats to Pam for receiving an Affinito-Stewart Grant and thank you to the PCCW for their support!
Kudos to Samantha for being awarded the CALS Outstanding TA Award!
Welcome new graduate students, Gael and Samantha!
Congratulations to Samantha for an Honorable Mention in the NSF GRFP competition this year!
Welcome CCB graduate student Bibudha Parasar to the lab!