The Chang Lab is a young, interdisciplinary lab at Cornell University working at the interface of chemical biology, immunology, microbial pathogenesis, and the gut microbiome. We are currently recruiting graduate students and postdoctoral scholars!
Our Commitment to Diversity, Equity, and Inclusion
Our research lab welcomes students, postdocs, and visiting scholars regardless of race/ethnicity, religion, gender identification, sexual orientation, socioeconomic background, age, disability, or caregiver status. We believe that a diverse and inclusive group with different perspectives, backgrounds, and abilities will enable us to see all possible solutions to a scientific problem, while fostering learning and growth in the best possible environment. Please reach out to learn more if you are interested in joining our team!
We are colonized by trillions of microorganisms, including bacteria, viruses, parasites, and fungi, which inhabit the external and internal surfaces of our bodies. It is becoming increasingly evident that these microbes play an important role in regulating many aspects of host physiology, including host defense and immunity. As a result, perturbations to the populations of commensal bacteria have been linked to many inflammatory diseases, including autoimmunity and chronic inflammatory conditions, and susceptibility to infections by microbial pathogens.
Our research focuses primarily on three areas:
(1) We develop activity-based probes to understand the metabolic activity catalyzed by the gut microbiome during different disease states.
(2) We also characterize the small-molecule metabolites produced by the gut microbiota that regulate inflammation during inflammatory diseases and host defense during infection with enteric pathogens.
(3) Building on these discoveries, we develop chemical tools to modulate the immune response using photo-immune modulators to understand the roles of specific immune cell types in vivo.
We employ biological and chemical approaches including the tools of microbiology, chemical biology, chemistry, biochemistry, and molecular and cellular immunology to elucidate key communication pathways between the gut microbiota and the host immune system. Our ultimate goal is to understand how immune homeostasis and host defense are regulated in the intestines, as such discoveries would have broad implications for the development of therapeutics and prophylactics for many inflammatory diseases.
For more information, please see the Research page.
Photo credit: Dennis Kunkel Microscopy
Congrats to Kien for his paper being accepted to Biochemistry!!
Check out Lin's review published in a special issue of Current Opinion in Chemical Biology!
The lab welcomes CHAMPS student, Noah Gerling, to the lab!!
Congrats to Kien for receiving the prestigious NSF GRFP this year!!
Check out Sam's exciting preprint on bioRxiv!!
Congratulations to Carolyn Bertozzi, Barry Sharpless, and Morten Meldal for winning the 2022 Nobel Prize in Chemistry! Read about some of our connections to the discoveries behind this year’s prize in the Cornell Chronicle and Nature.
Welcome, Raymond Xu, a new undergraduate, to the lab!
A big congratulations to Pam for being promoted to Associate Professor with tenure!!
Congrats to Kien for being selected as a CBI trainee!
Welcome CHAMPS student, Emilia Ceniceros! We're looking forward to having you in the lab.
Congratulations to Pam for receiving a Sloan Research Fellowship in Chemistry from the Alfred P. Sloan Foundation!
Congrats to Lin for passing her A-exam! Woohoo!!
Congrats to Sam for successfully defending her Ph.D. thesis! Kudos to Dr. Scott!
The lab welcomes Tracy Zheng, a CCB graduate student, to the group! Welcome, Tracy!!
The lab welcomes Kien Malarney, a Microbiology graduate student, to the group!
The lab bids a warm farewell to Bibudha Parasar and Amanda Conwell and wishes them the best of luck in the next chapter of their journey!
Congratulations to Bibudha for successfully defending his Ph.D. thesis! Way to go, Dr. Parasar!
Check out our video on our projects that are supported by the Arnold and Mabel Beckman Foundation!
The lab welcomes Gigi Uche Ike, a CHAMPS student, to the lab!! We're looking forward to having you in the group!
Congrats, JJ, on your new position! Good luck on your next chapter of life!
Check out Bibudha's First Reaction preview article in ACS Cent Sci!
Kudos to Bibudha, whose paper was accepted by JACS! A HUGE congrats!
The lab welcomes Amanda Conwell, a research technician, to the group! Welcome — we're excited to have you join us!
Congratulations to Samantha and JJ for their paper being accepted to PNAS! Bravo!!
Congrats to Pam for being named a Scialog Fellow! Way to go!!
The lab welcomes Lin Han, a CCB first-year graduate student, to the lab! We are happy to have you as part of the group, Lin!
Congratulations to Pam for receiving an NIH R35 Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators!
Check out Gael's review about metabolites and the gut microbiome, which is featured on the cover, in Trends in Pharmacological Sciences!
The Chang Lab participates in Expanding Your Horizons (EYH) Outreach Program at Cornell, continuing to inspire young women to pursue careers in STEM fields (check out our new photos in the gallery!).
Congratulations to Bibudha for his paper being accepted by ACS Central Science! Job well done!!
Kudos to Jingjing for receiving the prestigious CIHMID postdoctoral fellowship!! Congrats, JJ!
Welcome postdoctoral associate, Jingjing Fu, to the lab!!
Congratulations to Pam for winning the Schwartz Travel Award! See the article in the Cornell Chronicle.
Research in the Chang Lab was highlighted in the Cornell Chronicle at the recent joint Immunology symposium between the Weill Cornell and Ithaca campuses!
The Lab welcomes VLP summer student, Jiaming Huang, to the group! Hello, Jiaming!!
Congratulations to Gael for receiving an Honorable Mention for the Ford Foundation Predoctoral Fellowship!
Great job, Samantha, for passing her A exam! Congrats!!
The Chang Lab welcomes undergraduate Hyoann Choi to the group! Welcome, Hyoann!!
Our lab's research is the focus of Cornell Research! Go, Team!!
Congrats to Bibudha for passing his A exam! Way to go, Champ!!
Congratulations to Pam for receiving a Beckman Young Investigator Award and thank you to the Arnold and Mabel Beckman Foundation for their support! Check out the recent news article in the Cornell Chronicle.
Congrats to Samantha for receiving an NSF GRFP Honorable Mention!
Congrats to Pam for receiving an Affinito-Stewart Grant and thank you to the PCCW for their support!
Kudos to Samantha for being awarded the CALS Outstanding TA Award!
Welcome new graduate students, Gael and Samantha!
Congratulations to Samantha for an Honorable Mention in the NSF GRFP competition this year!
Welcome CCB graduate student Bibudha Parasar to the lab!